The project resulted in the development of novel array-based technologies as well as refinements to existing array technologies. Furthermore, the project added new array chips to the investigators’ existing chip collection and led to the development of new arrays, including protein arrays, transfected cell arrays and antibody arrays.
Functional genomics studies generate large amounts of data that require robust computational platforms. To address these needs, the investigators developed two Linux-based computational clusters and software to study gene expression, cell dynamics and protein-protein interactions.
The outcomes of this work were also collected in two new databases: the Online Human Predicted Interaction Database (OPHID), now called the I2D database, which predicts protein-protein interaction in the human interactome, and the HomologousDB database, used to determine the ancestral origins of related gene sequences.
In sum, this project refined existing functional genomics systems and launched new technologies that allow researchers to generate a more comprehensive portrait of cellular activities. Eventually, this may lead to the identification of specific molecular targets involved in disease progression.