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Dr. Yakunin focuses his research on Structural Proteomics and Enzymology.
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Dr. Yakunin focuses his research on Structural Proteomics and Enzymology.
EXPLORE >   Researchers >  Alexander Yakunin
Alexander Yakunin |
University of Toronto (UofT)
RESEARCH
BIOGRAPHY
KEY PUBLICATIONS
INTELLECTUAL PROPERTY
Research
Dr. Alexander Yakunin research interests revolve around understanding protein function. His studies involve enzyme discovery and enzyme genomics, enzymatic screening of unknown proteins for functional annotation, biochemical and structural characterization of novel enzymes. Dr. Yakunin also studies novel industrial enzymes for applications in bioremediation and biotechnology.
Researcher Information
Group leader
Chemical Engineering & Applied Chemistry
Website
C.H. Best Institute
112 College St. Room 23
Toronto, Ontario
Canada M5G 1L6
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Biography
Dr. Yaunin earned a M.Sc. degree in Molecular Biology at the Moscow State University in 1978. He then joined the Institute of Basic Biological Problems (former Institute of Photosynthesis) in Pushchino (Russia) where he studied nitrogen and hydrogen metabolism in photosynthetic bacteria with Dr. Ivan Gogotov. In 1987, he got his Ph.D. in Microbiology from the Institute of Microbiology (Moscow, Russia) for his work on regulation and enzymology of nitrogen fixation in Rhodobacter. He then continued his work as a Senior Researcher at the Institute of Basic Biological Problems (Pushchino, Russia) in the field of microbial nitrogen and hydrogen metabolism. From 1992 to 2002, Alex worked as a post-doctoral fellow and research associate with Dr. Patrick Hallenbeck at the University of Montreal where he studied enzymology and genetics of nitrogen fixation in Rhodobacter.
Researcher Information
Group leader
Chemical Engineering & Applied Chemistry
Website
C.H. Best Institute
112 College St. Room 23
Toronto, Ontario
Canada M5G 1L6


Key Publications
Clasquin MF, Melamud E, Singer A, Gooding JR, Xu X, Dong A, Cui H, Campagna SR, Savchenko A, Yakunin AF, Rabinowitz JD, Caudy AA.
Riboneogenesis in yeast.
Cell. 2011,145,6:969-80.
Makarova KS, Haft DH, Barrangou R, Brouns SJ, Charpentier E, Horvath P, Moineau S, Mojica FJ, Wolf YI, Yakunin AF, van der Oost J, Koonin EV.
Evolution and classification of the CRISPR-Cas systems.
Nat Rev Microbiol. 2011,9,6:467-77.
Chan PW, Yakunin AF, Edwards EA, Pai EF.
Mapping the reaction coordinates of enzymatic defluorination.
J Am Chem Soc. 2011 May 18;133(19):7461-8
Kuznetsova E, Proudfoot M, Sanders SA, Reinking J, Savchenko A, Arrowsmith CH, Edwards AM, Yakunin AF.
Enzyme genomics: application of general enzymatic screens to discover new enzymes.
FEMS Microbiol Rev. 2005 Apr; 29(2):263-79
Nocek B, Kochinyan S, Proudfoot M, Brown G, Evdokimova E, Osipiuk J, Edwards AM, Savchenko A, Joachimiak A, Yakunin AF.
Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria.
Proc Natl Acad Sci USA. 2008 Nov 18;105(46):17730-5
Researcher Information
Group leader
Chemical Engineering & Applied Chemistry
Website
C.H. Best Institute
112 College St. Room 23
Toronto, Ontario
Canada M5G 1L6


Intellectual Property

Researcher Information
Group leader
Chemical Engineering & Applied Chemistry
Website
C.H. Best Institute
112 College St. Room 23
Toronto, Ontario
Canada M5G 1L6
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CATEGORIES
Application Area
Bioproducts and biomaterials, Energy, Environment
Disciplinary Focus
Experimental biology and chemistry
Research Paradigm
Focused-scope projects, Large-scale projects, Technology development
Core Technology
Nucleic acids: DNA sequencing, Gene expression systems
Other molecules: High-throughput small molecule screening, Metabolites
Proteins: Enzymatic assays, Protein expression and purification
Organism
Human, Micro-organism
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