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My research interests like in identifying biomarkers of response or resistance to chemotherapy agents in breast and ovarian cancer. I am also interested in identifying clinically relevance mechanisms of drug resistance in cancer patients, which can be use to improve the therapeutic efficacy of chemotherapy.
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Researcher Information
Professor and Research Scientist
Department of Chemistry and Biochemistry
Website
Health Sciences North
41 Ramsey Lake Road, Room 32032
Sudbury, Ontario
Canada P3E 5J1
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Full Professor, Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada
Full Professor, Division of Medical Sceinces, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Affiliate Scientist, Health Sciences North, Sudbury, Ontario
Chief Scientific Officer, RNA Diagnostics, Inc.
Recipient, Premier's Research Excellence Award. CIHR Grants Panel Review Member (Cancer Progression and Therapeutics
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Researcher Information
Professor and Research Scientist
Department of Chemistry and Biochemistry
Website
Health Sciences North
41 Ramsey Lake Road, Room 32032
Sudbury, Ontario
Canada P3E 5J1
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Reed K, Parissenti AM The effect of ABCB1 genetic variants on chemotherapy response in HIV and cancer treatment. Pharmacogenomics (2011) 12(10): 1465-1483.
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Holleman A, Chung I, Olsen RR, Kwak B, Mizokami A, Saijo N, Parissenti A, Duan Z, Voest EE, Zetter BR miR-135a contributes to paclitaxel resistance in tumor cells both in vitro and in vivo. Oncogene (2011) 30(43): 4386-4398.
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Reed K, Hembruff SL, Sprowl JA, Parissenti AM The temporal relationship between ABCB1 promoter hypomethylation, ABCB1 expression and acquisition of drug resistance. Pharmacogenomics J. (2010) 10(6): 489-504.
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Reed K, Poulin ML, Yan L, Parissenti AM Comparison of bisulfite sequencing PCR with pyrosequencing for measuring differences in DNA methylation. Anal Biochem. (2010) 397(1) :96-106.
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Parissenti AM, Chapman JA, Kahn HJ, Guo B, Han L, O'Brien P, Clemons MP, Jong R, Dent R, Fitzgerald B, Pritchard KI, Shepherd LE, Trudeau ME. Association of low tumor RNA integrity with response to chemotherapy in breast cancer patients. Breast Cancer Res Treat. (2010) 119(2): 347-56.
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Researcher Information
Professor and Research Scientist
Department of Chemistry and Biochemistry
Website
Health Sciences North
41 Ramsey Lake Road, Room 32032
Sudbury, Ontario
Canada P3E 5J1
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A new method for monitoring response to chemotherapy in cancer patients by monitoring their ability to induce disruptions in RNA (the RNA Disruption Assay)
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A new method for monitoring response to chemotherapy in cancer patients by monitoring their ability to induce disruptions in RNA (the RNA Disruption Assay)
send a message
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ORGANIZATIONS
PROJECTS
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OTHER INFORMATION
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Researcher Information
Professor and Research Scientist
Department of Chemistry and Biochemistry
Website
Health Sciences North
41 Ramsey Lake Road, Room 32032
Sudbury, Ontario
Canada P3E 5J1
YOU MAY ALSO BE INTERESTED IN:
CATEGORIES
Disciplinary Focus
Clinical science,
Experimental biology and chemistry,
Molecular Pharmacology
Research Paradigm
Focused-scope projects,
Technology development
Core Technology
Cells and tissues:
Biobanking,
Cell imaging
Nucleic acids:
Cytogenomics,
Gene expression systems,
Genotyping,
Microarrays,
RNA technologies
Proteins:
Enzymatic assays,
Mass spectrometry,
Protein expression and purification
Organism
Human,
Micro-organism,
Rodent
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