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Dr. Brendan Frey develops methodologies and technologies for elucidating the rules underlying normal and diseased biological processes in genome science.
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Dr. Brendan Frey develops methodologies and technologies for elucidating the rules underlying normal and diseased biological processes in genome science.
EXPLORE >   Researchers >  Brendan Frey
RESEARCH
BIOGRAPHY
KEY PUBLICATIONS
INTELLECTUAL PROPERTY
Research
  • Gene regulation
  • Genetic networks
  • Alternative splicing
  • High-throughput data analysis (RNASeq, microarrays, imaging)
  • Organisms: Human, mouse, yeast
  • Machine learning algorithms
  • Graphical models, factor graphs and Bayesian networks
  • Probabilistic inference algorithms
Researcher Information
Professor
Engineering and Medicine
Website
Secondary Website
10 King's College Road
Toronto, Ontario
Canada M5S3G4
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Biography
Brendan Frey is a Professor and Canada Research Chair at the University of Toronto in the faculties of Engineering and Medicine. Dr. Frey's primary research interests include understanding gene regulation and alternative splicing, computational models of vision, and information processing and machine learning. His notable contributions include deciphering the splicing code (Nature 2010), clustering by affinity propagation (Science 2007), factor graphs and the sum product algorithm (IEEE Trans IT 2001) and the wake-sleep algorithm for unsupervised neural networks (Science 1995). Dr. Freyis a Fellow of the American Association for the Advancement of Science, an NSERC EWR Steacie Fellow, a Fellow of the Canadian Institute for Advanced Research, and a Fellow of the Institute of Electrical and Electronics Engineers.  His research group includes three postdoctoral fellows, seven graduate students and two technical staff. Dr. Frey has spent several years conducting research in the USA, England and India and has consulted for Microsoft Research and various information- and bio-technology companies.
Researcher Information
Professor
Engineering and Medicine
Website
Secondary Website
10 King's College Road
Toronto, Ontario
Canada M5S3G4


Key Publications
Y Barash, J Calarco, W Gao, Q Pan, X Wang, O Shai, BJ Blencowe, BJ Frey. Deciphering the splicing code. Nature 456, 53-59, May 2010.
Y Barash, BJ Blencowe, BJ Frey. A model-based approach to identifying alternative splicing signals. Bioinformatics 26:12, i325-i333, 2010.
BJ Frey and D Dueck. Clustering by passing messages between datapoints. Science 315, 972-976, February 2007.
JC Huang, T Babak, TW Corson, G Chua, S Khan, BL Gallie, TR Hughes, BJ Frey, QD Morris. Using expression profiling data to identify human microRNA targets. Nature Methods 4:12,1049-1055, November 2007.
BJ Frey, N Mohammad, QD Morris, W Zhang, MD Robinson, S Mnaimneh, R Chang, Q Pan, N Laurin, E Sat, J Rossant, BG Bruneau, J Aubin, B Blencowe, TR Hughes. Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs. Nature Genetics 37:9, 991-996, September 2005.
Researcher Information
Professor
Engineering and Medicine
Website
Secondary Website
10 King's College Road
Toronto, Ontario
Canada M5S3G4


Intellectual Property

Researcher Information
Professor
Engineering and Medicine
Website
Secondary Website
10 King's College Road
Toronto, Ontario
Canada M5S3G4
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CATEGORIES
Application Area
Human health, Instrumentation and tools
Disciplinary Focus
Informatics, theoretical biology and computer science, Mathematics and engineering
Research Paradigm
Focused-scope projects, Technology development
Core Technology
Nucleic acids: DNA sequencing, Gene expression systems, Microarrays, RNA technologies
Proteins: Mass spectrometry
Organism
Human, Rodent, yeast
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