Dr. Guidos’ current research is aimed at studying the molecular mechanisms that regulate survival, proliferation and commitment during lymphocyte development. Understanding these processes is important because defects in this process are known to cause lymphoblastic leukemia and immune deficiency.

A long-standing research focus involves studying the mechanisms of leukemo- and lymphomagenesis. This includes the study of signaling pathways that regulate cell proliferation, differentiation and survival in normal and neoplastic lymphoid cells. This includes a current large-scale research initiative led by Dr. Guidos and involving other senior investigators from The Hospital for Sick Children and University Health Network, to identify and study leukemia-initiating cell(s), or leukemia stem cells.

Other research interests include utilizing a number of biochemical and genetic approaches to study the role of the Notch signaling pathway in T- and B-cell development.

Dr. Guidos is currently Senior Scientist in Developmental & Stem Cell Biology at The Hospital for Sick Children Research Institute, and Professor of Immunology in the Faculty of Medicine at the University of Toronto. She is also Scientific Director of The Flow Cytometry Facility and Principal Investigator of the Leukemia Research Group, both based at The Hospital for Sick Children. She has received a Medical Research Council of Canada Scientist Research award. Dr. Guidos received a PhD in Medical Sciences (Immunology) from the University of Alberta in 1986.