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Dr. Cvitkovitch’s research interests include microbial agents of dental decay, and the development of novel biomaterials.
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Dr. Cvitkovitch’s research interests include microbial agents of dental decay, and the development of novel biomaterials.
EXPLORE >   Researchers >  Dennis Cvitkovitch
Dennis Cvitkovitch |
University of Toronto (UofT)
RESEARCH
BIOGRAPHY
KEY PUBLICATIONS
INTELLECTUAL PROPERTY
Research
Dr. Dennis Cvitkovitch’s research interests focus on the role of the acid tolerance response of Streptococcus mutans, the principal agent of dental decay. Using a variety of molecular biological, biochemical and in silico technologies, Dr. Cvitkovitch and his research group are also unraveling the mechanisms of cell-cell signaling and its role in biofilm formation and genetic exchange by gram positive pathogens. Ongoing collaborative programs also include the search for potential vaccine targets for Streptococcus pyogenes infections and the effects of dental restorative materials on bacterial growth and metabolism. The group is also integrated with the University of Toronto Tissue Engineering Group focusing on the development of novel biomaterials resistant to bacterial infection. Dr. Cvitkovitch is the inventor of the Competence Stimulating Peptide (CSP) technology which is based upon the discovery that CSP is associated with the formation of dental plaque, which can lead to dental cavities, periodontal diseases, and infective endocarditis. The technology includes inhibitors of CSP that have been shown to prevent CSP from performing its essential role in plaque formation. A biotechnology company engaged in the development of products to prevent and remove biofilms has exclusive licensing to the CSP technology.
Researcher Information
Associate Professor
Oral Microbiology
Rm 449A, Faculty of Dentistry
124 Edward Street
Toronto, Ontario
Canada M5G 1G6
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Biography
Dr. Dennis Cvitkovitch received his PhD in Oral Microbiology from the University of Manitoba in Winnipeg in 1995 and went on to pursue Post Doctoral research at the University of Florida in the Department of Oral Biology. He has been a recipient of the Canada Research Chair from 2001-2006.
Researcher Information
Associate Professor
Oral Microbiology
Rm 449A, Faculty of Dentistry
124 Edward Street
Toronto, Ontario
Canada M5G 1G6


Key Publications
Suntharalingam P, Senadheera MD, Mair RW, Lévesque CM, Cvitkovitch DG. The LiaFSR system regulates the cell envelope stress response in Streptococcus mutans. J Bacteriol. 2009 May;191(9):2973-84
Korithoski B, Lévesque CM, Cvitkovitch DG. The involvement of the pyruvate dehydrogenase E1alpha subunit, in Streptococcus mutans acid tolerance. FEMS Microbiol Lett. 2008 Dec;289(1):13-9.
Khalichi P, Singh J, Cvitkovitch DG, Santerre JP. The influence of triethylene glycol derived from dental composite resins on the regulation of Streptococcus mutans gene expression. Biomaterials. 2009 Feb;30(4):452-9.
Senadheera D, Cvitkovitch DG. Quorum sensing and biofilm formation by Streptococcus mutans. Adv Exp Med Biol. 2008;631:178-88.
Korithoski B, Lévesque CM, Cvitkovitch DG. Involvement of the detoxifying enzyme lactoylglutathione lyase in Streptococcus mutans aciduricity. J Bacteriol. 2007 Nov;189(21):7586-92.
Researcher Information
Associate Professor
Oral Microbiology
Rm 449A, Faculty of Dentistry
124 Edward Street
Toronto, Ontario
Canada M5G 1G6


Intellectual Property

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CATEGORIES
Application Area
Bioproducts and biomaterials, Human health
Disciplinary Focus
Clinical science, Experimental biology and chemistry
Research Paradigm
Focused-scope projects, Technology development
Organism
Human
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