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Dr. Brown’s lab researchers are currently studying cell wall and ribosome biogenesis, both daunting cellular processes of remarkable complexity. Further, Dr. Brown oversees an ambitious effort in chemical genomics aimed at mapping and understanding the interaction of drug-like small molecules with bacterial cell systems.
Currently, the Brown’s lab has mounted research projects in areas of bacterial physiology of emerging importance in antibacterial drug discovery.
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Researcher Information
Chair
Biochemistry & Biomedical Sciences
Website
1200 Main St W
Hamilton, Ontario
Canada L8N 3Z5
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Dr. Brown earned his Ph.D. in 1992 in Biochemistry studying of proline utilization in bacteria at the University of Guelph. Dr. Brown then spent 2 years as a Natural Sciences and Engineering Research Council of Canada postdoctoral fellow in at Harvard Medical School researching bacterial cell wall biosynthesis. Dr. Brown worked for three years in the Boston pharmaceutical sector with Myco Pharmaceuticals and Astra Research Center Boston before joining the Department of Biochemistry at McMaster in 1998 and receiving a Medical Research Council of Canada Scholarship.
Dr. Brown has been the recipient of a variety of investigator awards including a Canada Research Chair in Chemical Biology and the Merck Frosst Prize.
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Researcher Information
Chair
Biochemistry & Biomedical Sciences
Website
1200 Main St W
Hamilton, Ontario
Canada L8N 3Z5
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Falconer SB, Czarny TL, Brown ED. Antibiotics as probes of biological complexity. Nat Chem Biol. 2011,17:415-423.
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Allison SE, D'Elia MA, Arar S, Monteiro MA, Brown ED. Studies of the Genetics, Function, and Kinetic Mechanism of TagE, the Wall Teichoic Acid Glycosyltransferase in Bacillus subtilis 168. J Biol Chem. 2011 Jul 8;286(27):23708-16
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Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK, Tyers M, Brown ED, Wright GD. Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nat Chem Biol. 2011,7,6:348-50.
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Jomaa A, Stewart G, Martín-Benito J, Zielke R, Campbell TL, Maddock JR, Brown ED, Ortega J. Understanding ribosome assembly: the structure of in vivo assembled immature 30S subunits revealed by cryo-electron microscopy. RNA. 2011,17,4:697-709.
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Researcher Information
Chair
Biochemistry & Biomedical Sciences
Website
1200 Main St W
Hamilton, Ontario
Canada L8N 3Z5
|
 |
 |
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YOU MAY ALSO BE INTERESTED IN:
CATEGORIES
Disciplinary Focus
Clinical science,
Experimental biology and chemistry,
Informatics, theoretical biology and computer science
Core Technology
Proteins:
Protein expression and purification,
Protein sequencing,
Protein-protein interaction assays
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