RESEARCHERS
 
LOG IN
SIGN-UP
SEARCH
JUMP TO ADVANCED SEARCH
                                            
Development of smart nanomaterials for therapeutic and diagnostic applications.
Welcome to the Genomics Sector Innovation Network (G-SIN) portal

Development of smart nanomaterials for therapeutic and diagnostic applications.
EXPLORE >   Researchers >  Frank Gu
RESEARCH
BIOGRAPHY
KEY PUBLICATIONS
INTELLECTUAL PROPERTY
Research
Dr. Gu is a nanotechnology engineer, expert in the development of nanotherapeutics and diagnostic modalities targeting human and animal diseases. His research on the formulation of disease-targeted nanoparticles has generated over 20 papers, and 15 US and World pending patent applications. His technologies related to the precise engineering of therapeutic nanoparticles have been licensed to several biotechnology companies including BIND Biosciences and Selecta Biosciences as their core technologies for the manufacturing of clinical grade targeted nanoparticles. Frank Gu’s Laboratory has recently developed reusable nanoparticles that can target and capture protein and nucleic acid biomarkers at picogram concentration in vitro. Such technologies may be used for recovering unique targets for genomics and proteomics applications.
Researcher Information
Assistant Professor
Chemical Engineering
Website
200 University Ave West
Waterloo, Ontario
Canada N2L3G1
Send a message
Log In to mark favourites


Biography
Frank Gu received his Ph.D. in Chemical Engineering at Queen’s University in Canada. During his Ph.D. program, he was awarded the Japanese Society the Promotion of Science (JSPS) summer fellowship to work on nanoparticle formulation at the University of Tokyo. In 2006, he was award with NSERC Postdoctoral Fellowship to join the Laboratory of Professor Robert Langer lab at Massachusetts Institute of Technology (MIT), where he pursued in-depth research training in nanomedicine and drug delivery. Dr. Gu joined the Department of Chemical Engineering at the University of Waterloo, and was subsequently cross-appointed to the Waterloo Institute of Nanotechnology. His current research interests are in the development of nanotherapeutics and diagnostic modalities targeting human and animal diseases.
Researcher Information
Assistant Professor
Chemical Engineering
Website
200 University Ave West
Waterloo, Ontario
Canada N2L3G1


Key Publications
Dhar S, Gu FX, Langer R, Farokhzad OC, Lippard SJ‡. Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proceedings of the National Academy of Sciences of the USA. 2008. 105(45):17356-17361
Zhang LF, Chan JM, Gu F, Rhee JW, Wang AZ, Radovic-Moreno AF, Alexis F, Langer R‡, Farokhzad OC‡. Self-assembled lipid-polymer hybrid nanoparticles: A robust drug delivery platform. ACS Nano. 2008. 2(8):1696-1702.
Gu F, Zhang L, Teply BA, Mann N*, Wang A, Radovic-Moreno AF, Langer R‡, Farokhzad OC‡. Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers. Proceedings of National Academy of Sciences of the USA. 2008. 105(7):2586-2591.
Zhang L, Gu FX, Chan JM, Wang AZ, Langer RS‡, Farokhzad OC‡. Nanoparticles in medicine: therapeutic applications and developments. Clinical Pharmacology and Therapeutics. 2008. 83(5)761-769.
Gu FX, Karnik R, Wang AZ, Alexis F, Levy-Nissenbaum E, Hong S, Langer R, Farokhzad OC‡. Targeted nanoparticles for cancer therapy. Nano Today. 2007. 2(3):14-21.
Researcher Information
Assistant Professor
Chemical Engineering
Website
200 University Ave West
Waterloo, Ontario
Canada N2L3G1


Intellectual Property

Researcher Information
Assistant Professor
Chemical Engineering
Website
200 University Ave West
Waterloo, Ontario
Canada N2L3G1
YOU MAY ALSO BE INTERESTED IN:


CATEGORIES
Application Area
Agriculture, Animal health, Bioproducts and biomaterials, Environment
Disciplinary Focus
Clinical science, Experimental biology and chemistry, Mathematics and engineering
Research Paradigm
Focused-scope projects, Large-scale projects, Technology development
Core Technology
Any other technology: intracellular targeting
Cells and tissues: Cell imaging
Nucleic acids: Microarrays, RNA technologies
Other molecules: Lipid-based technologies
Proteins: Enzymatic assays, Protein chips, Protein expression and purification
Organism
Human, Micro-organism, Nematode and worm, Plant
Sign-up to edit this profile
Events Jobs What is Genomics Genomics in Canada About Us Contact Us Privacy Policy Terms of Use Site-Map
© Ontario Genomics Institute, 2007-2013.