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Dr. Guri Giaever uses chemical genetics to screen protein-inhibiting compounds in an effort to discover new drugs.
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Dr. Guri Giaever uses chemical genetics to screen protein-inhibiting compounds in an effort to discover new drugs.
EXPLORE >   Researchers >  Guri Giaever
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Dr. Guri Giaever is at the forefront of an effort to screen compounds that lead to the discovery of new drugs. She uses chemical genetics rather than classical genetics to understand the inner workings of the cell, applying chemical compounds to inhibit the proteins produced by genes. Giaever's chemogenomic assay, HaploInsufficiency Profiling (HIP), for studying how chemicals and drugs operate is targeted to brewer's yeast - an organism that shares 50 percent of its genetic material with humans. She works with a collection of strains of yeast, each of which has a single gene deleted, and using chemical genetics allows her to apply drugs and identify targets more easily than with other methods. Unlike genetic mutations, creating chemical mutations is fast, reversible, and "tunable." The primary focus of Dr. Giaever’s research is to screen known and novel antiproliferatives to identify drug targets, screen high-throughput compounds, and to explore essential gene function in yeast. This assay allows for parallel analysis and relative strain fitness to be quantitatively assessed by hybridization to oligonucleotide arrays. And finally, Giaever and her team are also screening 50,000 previously untested compounds with the aim of "matching" them against essential proteins inside the cells to better understand the function of all the essential proteins inside cells. By studying pathway-specific synthetic genetic effects of a particular compound on a pathway using Homozygous deletion Profiling (HOP) screening, genes that buffer inhibition of the target pathway will be uncovered resulting in better understanding of the pathway.
Researcher Information
Assistant Professor
Faculty of Pharmacy
160 College St.
Rm1208
Toronto, Ontario
Canada M5S3E1
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Biography
Dr. Giaever was awarded the Canada Research Chair in Chemical Genetics in 2006. Dr. Giaver is the Laboratory Director at the Stanford Genome Technology Center and an Assistant Professor in the Faculty of Pharmacy at the University of Toronto.
Researcher Information
Assistant Professor
Faculty of Pharmacy
160 College St.
Rm1208
Toronto, Ontario
Canada M5S3E1


Key Publications
Pierce SE, Davis RW, Nislow C, Giaever G. Chemogenomic approaches to elucidation of gene function and genetic pathways. Methods Mol Biol. 2009;548:115-43.
Yan Z, Berbenetz NM, Giaever G, Nislow C. Precise gene dose alleles for chemical genetics.Genetics. 2009 Mar 30.
Giaever G, Nislow C. Knocking sense into regulatory pathways. Nat Biotechnol. 2009 Feb. 27(2):149-50.
Hillenmeyer ME, Fung E, Wildenhain J, Pierce SE, Hoon S, Lee W, Proctor M, St.Onge RP, Tyers M, Koller D, Altman RB, Davis RW, Nislow C, Giaever G. The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science. 2008. Apr. 18; 320(5874):362-365.
Pierce SE, Davis RW, Nislow C and Giaever G. Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures. Nat Protoc. 2007;2(11):2958-74.
Researcher Information
Assistant Professor
Faculty of Pharmacy
160 College St.
Rm1208
Toronto, Ontario
Canada M5S3E1


Intellectual Property

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CATEGORIES
Application Area
Human health, Instrumentation and tools
Disciplinary Focus
Clinical science, Experimental biology and chemistry
Research Paradigm
Focused-scope projects, Large-scale projects, Technology development
Organism
Human, Microorganism
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