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CEO and Founder of Proteins Easy Corporation, Inventor on US Patent 7,214,862 Production of Human Granulocyte Macrophage-Colony Stimulating Factor in Plants. May 8, 2007.
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CEO and Founder of Proteins Easy Corporation, Inventor on US Patent 7,214,862 Production of Human Granulocyte Macrophage-Colony Stimulating Factor in Plants. May 8, 2007.
EXPLORE >   Researchers >  Illimar Altosaar
Illimar Altosaar
RESEARCH
BIOGRAPHY
KEY PUBLICATIONS
INTELLECTUAL PROPERTY
Research
Large scale production of recombinant proteins
Protein farming in genetically engineered crops
Molecular biopharming, plants with novel traits, recombinant protein expression systems

"The present invention discloses a method of producing granulocyte-macrophage colony stimulating factor (GM-CSF) in a plant comprising, transforming the plant with a genetic construct comprising a regulatory region functional in the plant, operably associated with a GM-CSF coding sequence, or a fragment or a derivative thereof, operably associated with a transcriptional terminator, and expressing the GM-CSF. Also disclosed are transgenic plants, seeds and cells comprising GM-CSF coding sequences and plant optimized GM-CSF coding sequences."
Researcher Information
Chief Scientific Officer
Proteins Easy Corporation
Website
950 Weston Drive
Elmvale Acres
Ottawa, Ontario
Canada K1G 1X2
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Biography
CEO and Founder of Proteins Easy Corporation, Inventor on US Patent 7,214,862 Production of Human Granulocyte Macrophage-Colony Stimulating Factor in Plants. May 8, 2007.
Researcher Information
Chief Scientific Officer
Proteins Easy Corporation
Website
950 Weston Drive
Elmvale Acres
Ottawa, Ontario
Canada K1G 1X2


Key Publications
Cheng, X., Sardana, R., Kaplan, H., and Altosaar, I. 1998. Agrobacterium-transformed rice plants expressing synthetic CryIA(b) and CryIA(c) genes are highly toxic to yellow stem borer and striped stem borer. Proc. Natl. Acad. Sci. (USA) 95(6): 2767-2772
Blais DR and Altosaar I. 2006. Human CD14 expressed in seeds of transgenic tobacco displays similar proteolytic resistance and bioactivity with its mammalian-produced counterpart. Transgenic Research 15:151-164
Tackaberry ES, Prior FA, Rowlandson K, Tocchi M, Mehic J, Porter S, Walsh M, Schleiss MR, Ganz PR, Sardana RK, Altosaar I and Dudani AK. 2008. Sustained expression of human cytomegalovirus glycoprotein B (UL55) in the seeds of homozygous rice plants. Molecular Biotechnology, 2008 Sep; 40(1): 1-12.
Blais DR and Altosaar I. 2007. Humanizing infant milk formula to decrease postnatal HIV transmission. Trends in Biotechnology 25: 376-384
Sardana RK, Dudani AK, Tackaberry E, Alli Z, Porter S, Rowlandson K, Ganz P, Altosaar I. 2007. Biologically active human GM-CSF produced in the seeds of transgenic rice plants. Transgenic Research, 16:713721.
Researcher Information
Chief Scientific Officer
Proteins Easy Corporation
Website
950 Weston Drive
Elmvale Acres
Ottawa, Ontario
Canada K1G 1X2


Intellectual Property
Production of GM-CSF in Plants
a method of producing granulocyte-macrophage colony stimulating factor (GM-CSF) in a plant.

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a method of producing granulocyte-macrophage colony stimulating factor (GM-CSF) in a plant.

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CATEGORIES
Application Area
Agriculture, Animal health, Bioproducts and biomaterials, Energy, Environment, Human health, Natural resources
Disciplinary Focus
Experimental biology and chemistry
Research Paradigm
Focused-scope projects, Large-scale projects, Technology development
Core Technology
high throughput gene screen functional assay for antimicrobial peptides
Nucleic acids: Gene expression systems
Other molecules: High-throughput small molecule screening
Organism
Plant, Plant, rice endosperm granule platform
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