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The de Azavedo lab is utilizing a novel mouse model to study bacterial virulence determinants and antimicrobial resistance mechanisms.
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The de Azavedo lab is utilizing a novel mouse model to study bacterial virulence determinants and antimicrobial resistance mechanisms.
EXPLORE >   Researchers >  Joyce de Azavedo
Joyce de Azavedo |
Mount Sinai Hospital
RESEARCH
BIOGRAPHY
KEY PUBLICATIONS
INTELLECTUAL PROPERTY
Research
Dr. de Azavedo’s interests include the molecular study of gram-positive bacterial virulence determinants and antibiotic resistance mechanisms. Recent studies include the development of a novel murine pneumonia model for the investigation of drug efficacy and emergence of resistance and identification of novel virulence determinants in Group A Streptococcus and Streptococcus iniae. Dr. de Azavedo also leads The Toronto Centre for Antimicrobial Research & Evaluation (ToCARE) group, a fee for service research group which operates from the internationally recognized Mount Sinai Hospital. ToCARE is primarily involved in the study of the molecular mechanisms of antimicrobial resistance as well as offering services in the areas of pharmacokinetics, immunology, and surveillance. The research team has the capabilities to study the activity and effectiveness of various antibiotics, the mechanisms of drug resistance, to quantify antibody and cytokine levels, and to determine host-pathogen interactions.
Researcher Information
Research Scientist
Microbiology
600 University Ave
Room 1483
Toronto, Ontario
Canada M5G 1X5
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Biography
Dr. Joyce de Azavedo is an Associate Professor of Microbiology in the Department of Laboratory Medicine and Pathobiology at the University of Toronto, Research Scientist at Mount Sinai Hospital and Director of the Toronto Centre for Antimicrobial Research and Evaluation (ToCARE). Dr. de Azavedo obtained her PhD in Microbiology from the Department of Microbiology at Trinity College in Dublin, Ireland. Following a research fellowship at the Pasteur Institute, France, she worked in the Vaccine Research section of the Wellcome Research Laboratories in London, England and also at the Samuel Lunenfeld Research Institute in Toronto. Dr. de Azavedo has presented her work at numerous  national and international conferences, and has published several papers in high-impact peer-reviewed infectious diseases journals including Infection and Immunity, Molecular Microbiology, Antimicrobial Agents and Chemotherapy, Journal of Antimicrobial Chemotherapy, New England Journal of Medicine and Clinical Infectious Diseases. She has also has written a review article on Fluoroquinolone Resistance and a book chapter on Streptolysin S.
Researcher Information
Research Scientist
Microbiology
600 University Ave
Room 1483
Toronto, Ontario
Canada M5G 1X5


Key Publications
Salim KY, de Azavedo JC, Bast DJ, Cvitkovitch DG. Regulation of sagA, siaA and scpC by SilCR, a putative signaling peptide of Streptococcus pyogenes. FEMS Microbiol Lett. 2008 Dec;289(2):119-25.


Bolotin S, Fuller JD, Bast DJ, de Azavedo JC. The two-component system sivS/R regulates virulence in Streptococcus iniae. FEMS Immunol Med Microbiol. 2007 Dec;51(3):547-54.
Bolotin S, Fuller JD, Bast DJ, Beveridge TJ, de Azavedo JC. Capsule expression regulated by a two-component signal transduction system in Streptococcus iniae. FEMS Immunol Med Microbiol. 2007 Aug;50(3):366-74.
Researcher Information
Research Scientist
Microbiology
600 University Ave
Room 1483
Toronto, Ontario
Canada M5G 1X5


Intellectual Property

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CATEGORIES
Application Area
Human health
Disciplinary Focus
Experimental biology and chemistry
Research Paradigm
Focused-scope projects
Organism
Human, Microorganism, Rodent
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