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In the Pawson laboratory, Dr. Colwill has been investigating the role of kinases and adapter proteins in signal transduction. By combining mass spectrometry techniques for both identification and quantification of protein complexes as well as high throughput screening using RNAi, we are starting to understand the role that these proteins play in signal transduction.
In addition, Dr. Colwill is the Project Manager for a software enterprise application termed OpenFreezer that tracks reagents within their laboratory including their relevant features and locations. OpenFreezer is currently tracking over 150,000 reagents at the Samuel Lunenfeld Research Institute.
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Researcher Information
Staff Scientist
Website
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
600 University Avenue, Room 970
Toronto, Ontario
Canada M5G 1X5
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Dr. Karen Colwill is a staff scientist in the laboratory of Dr. Anthony (Tony) Pawson at the Samuel Lunenfeld Research Institute. Dr. Colwill received her PhD as a student in Dr. Pawson's laboratory and performed post-doctoral studies with Dr. Brenda Andrews. After working for several years in industry, Dr. Colwill returned to the laboratory of Dr. Pawson in order to manage several large scale projects including the recently concluded "Dynactome" project.
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Researcher Information
Staff Scientist
Website
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
600 University Avenue, Room 970
Toronto, Ontario
Canada M5G 1X5
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Colwill K., Persson H., Jarvik N. E., Wyrzucki A., Wojcik J., Koide A., Kossiakoff A. A., Koide S., Sidhu S., Dyson M. R., Pershad K., Pavlovic J. D., Karatt-Vellatt A., Schofield D. J., Kay B. K., McCafferty J., Mersmann M., Meier D., Mersmann J., Helmsing S., Hust M., Dubel S., Berkowicz S., Freemantle A., Spiegel M., Sawyer A., Layton D., Nice E., Dai A., Rocks O., WillitonK. , Fellouse F. A., Hersi K., Pawson T., Nilsson P., Sundberg M. , Sjoberg R., Sivertsson A., Schwenk J. M., Takanen J. O., Hober S., Uhlen M., Dahlgren L. G., Flores A., Johansson I., Weigelt J., Crombet L., Loppnau P., Kozieradzki I., Cossar D., Arrowsmith C. H., Edwards A. M. and Graslund S. "A roadmap to generate renewable protein binders to the human proteome." Nat Methods. (2011).
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Linding, R., Jensen L. J. , Ostheimer G. J. , van Vugt M. A., Jorgensen C., Miron I. M., Diella F., Colwill K., Taylor L., Elder K., Metalnikov P., Nguyen V., Pasculescu A., Jin J., Park J. G., Samson L. D., Woodgett J. R., Russell R. B., Bork P., Yaffe M. B. and Pawson t. "Systematic discovery of in vivo phosphorylation networks." Cell (2007) 129(7): 1415-1426.
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Wells, C. D., Fawcett J. P., Traweger A., Yamanaka Y., Goudreault M., Elder K., Kulkarni S., Gish G., Virag C., Lim C., Colwill K., Starostine A., Metalnikov P. and Pawson T. "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells." Cell (2006) 125(3): 535-548.
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Colwill, K., Wells C. D. , Elder K., Goudreault M., Hersi K., Kulkarni S., Hardy W. R., Pawson T. and Morin G. B. "Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites." BMC Biotechnol. (2006) 6: 13.
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Researcher Information
Staff Scientist
Website
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
600 University Avenue, Room 970
Toronto, Ontario
Canada M5G 1X5
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CATEGORIES
Disciplinary Focus
Experimental biology and chemistry,
Informatics, theoretical biology and computer science
Core Technology
Cells and tissues:
Cell imaging
Nucleic acids:
DNA sequencing
Proteins:
Mass spectrometry,
Protein expression and purification,
Protein-protein interaction assays
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