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Pearl Campbell's research focuses on gaining mechanistic insight into the factors that regulate the primitive pluripotent state.
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Pearl Campbell's research focuses on gaining mechanistic insight into the factors that regulate the primitive pluripotent state.
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Pearl Campbell's research focuses on gaining mechanistic insight into the factors that regulate the primitive pluripotent state. Recent evidence suggests that this state is enforced through epigenetic mechanisms that result in the co-localization of co-activator and co-repressor complexes at developmentally regulated loci. In pluripotency, these complexes act to maintain competence at developmentally regulated loci. However, due to the presence of Polycomb group (PcG) proteins and other factors, these loci remain repressed. Through a combination of genomic, proteomic, and bioinformatic techniques, we hope to gain insight into how changing signal transduction cascades may impact post-translational regulation of transcription factor function. This insight will allow us to better understand the combinatorial epiproteomic signature that maintains self-renewal and permits cell fate transitions. We hope to use this information to better understand the molecular mechanisms that guide normal development and how their dysregulation may lead to human disease such as cancer.
Researcher Information
Director, StemCore Laboratories
Regenerative Medicine Program
Website
501 Smyth Road
Ottawa, Ontario
Canada K1H 8L6
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Biography
Director, StemCore Laboratories
Researcher Information
Director, StemCore Laboratories
Regenerative Medicine Program
Website
501 Smyth Road
Ottawa, Ontario
Canada K1H 8L6


Key Publications
Perez-Iratxeta, C., G. Palidwor, C.J. Porter, N.A. Sanche, M.R. Huska, B.P. Suomela, E.M. Muro, P.M. Krzyzanowski, E. Hughes, P.A. Campbell, M.A. Rudnicki, and M.A. Andrade. Study of stem cell function using microarray experiments. FEBS Lett. 2005, 579:1795-1801.
Sene, K.H., C.J. Porter, G. Palidwor, C. Perez-Iratxeta, E.M. Muro, P.A. Campbell, M.A. Rudnicki, and M.A. Andrade-Navarro. Gene function in early mouse embryonic stem cell differentiation. BMC Genomics. 2007, 8:85
Campbell, P.A., Perez-Iratxeta, C., Andrade, M.A., and Rudnicki, M.A. Oct4 targets regulatory nodes to modulate stem cell function. PLoS One. 2007, 2(6): e553. doi:10.1371.
Campbell, P.A., and Rudnicki, M.A. (2013). Oct4 Interaction with Hmgb2 Regulates Akt Signaling and Pluripotency. Stem Cells, Forthcoming
Researcher Information
Director, StemCore Laboratories
Regenerative Medicine Program
Website
501 Smyth Road
Ottawa, Ontario
Canada K1H 8L6


Intellectual Property

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CATEGORIES
Application Area
Human health
Disciplinary Focus
Experimental biology and chemistry
Research Paradigm
Focused-scope projects, Large-scale projects, Technology development
Core Technology
Nucleic acids: DNA sequencing, Gene expression systems, Microarrays
Proteins: Protein expression and purification, Protein-protein interaction assays
Organism
Human, Rodent
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