Dr. St George-Hyslop’s research centres around mapping, cloning and functional characterization of genes associated with human neurodegenerative diseases with a specific emphasis on Alzheimer ’s disease. Unraveling this neurodegenerative process will be helpful in designing potential therapeutics and providing insight into other neurodegenerative diseases such as Parkinson’s disease, Frontotemporal Dementia, Amyotrophic lateral sclerosis (ALS) or Motor Neuron Disease and Prion diseases.

The. George-Hyslop group also is interested is understanding  the role of the presenilin complex in neurodegenerative disease and characterizing the individual components of this complex and how they function.

Dr. St George-Hyslop is a Professor in the Department of Medicine, Division of Neurology, at the University of Toronto. He is an internationally acclaimed geneticist and physician and received his M.D from University of Ottawa in 1976.and an F.R.C.P.(C) in internal medicine and in neurology from the Royal College of Physicians of Canada. Further, he did post-graduate work in internal medicine and neurology at the University of Toronto. He conducted post-doctoral research at Harvard Medical School where he also became an instructor in molecular genetics and neurology from 1987 to 1991. In 1991, he was appointed to the Faculty of Medicine at the University of Toronto as an Assistant Professor of Medicine and was promoted to Professor in 1996. He became a Director of the Centre for Research in Neurodegenerative Diseases in 1995.

Dr. St George-Hyslop is also a practicing neurologist and attends in the ward at the University Health Network teaching hospitals.